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Generic Name & Formulations: Sumatriptan (as succinate) 25mg, 50mg, 100mg Imitrex oral tablets are available in three strengths: 25 milligrams (mg) 50 mg. Ubrelvy and Imitrex are both oral tablets used to treat migraine, but there are differences in the way they work. Ubrelvy prevents a protein called CGRP thought to play a role in migraine attacks from binding to its receptor and Imitrex is thought to bind to serotonin 5‑HT1B/1D receptors, and inhibit pro-inflammatory substances Although no head-to-head comparison trials compare Ubrelvy to. Imitrex is used in the treatment of cluster headaches; migraine and belongs to the drug class antimigraine agents. [2] Common side effects include chest pressure, fatigue, vomiting, tingling, and vertigo. Generic Name & Formulations: Sumatriptan (as succinate) 25mg, 50mg, 100mg Sumatriptan, sold under the brand name Imitrex among others, is a medication used to treat migraine headaches and cluster headaches. 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